Developing hyperpolarized silicon particles forin vivoMRI targeting of ovarian cancer

In vivo magnetic resonance imaging of hyperpolarized silicon particles.

Silicon-based micro- and nanoparticles have gained popularity in a wide range of biomedical applications due to their biocompatibility and biodegradability in vivo, as well as their flexible surface chemistry, which allows drug loading, functionalization and targeting. Here, we report direct in vivo imaging of hyperpolarized (29)Si nuclei in silicon particles by magnetic resonance imaging. Natu...

Real-Time MRI-Guided Catheter Tracking Using Hyperpolarized Silicon Particles

Visualizing the movement of angiocatheters during endovascular interventions is typically accomplished using x-ray fluoroscopy. There are many potential advantages to developing magnetic resonance imaging-based approaches that will allow three-dimensional imaging of the tissue/vasculature interface while monitoring other physiologically-relevant criteria, without exposing the patient or clinici...

Epigenetic targeting of ovarian cancer stem cells.

Emerging results indicate that cancer stem-like cells contribute to chemoresistance and poor clinical outcomes in many cancers, including ovarian cancer. As epigenetic regulators play a major role in the control of normal stem cell differentiation, epigenetics may offer a useful arena to develop strategies to target cancer stem-like cells. Epigenetic aberrations, especially DNA methylation, sil...

Targeting Paclitaxel-Loaded Nanoparticles To Ovarian Cancer

VEGF Targeting Agents in Ovarian Cancer

Angiogenesis, the formation of new blood vessels, is a critical component in the growth and metastasis of cancers and has been recognized as an attractive target for anticancer therapy (Ferrara, 2002). Among the pro-angiogenic factors, vascular endothelial growth factor (VEGF) is recognized as the predominant mediator of angiogenesis in tumor cells (Ferrara & Kerbel, 2005). As VEGF is overexpre...